SrasV1, Main, Exploration, bibRecord, 001F60

Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents

Identifieur interne : 001F60 ( Main/Exploration ); précédent : 001F59; suivant : 001F61

Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents

Auteurs : Li-Jun Wang [République populaire de Chine] ; Chang-An Geng [République populaire de Chine] ; Yun-Bao Ma [République populaire de Chine] ; Xiao-Yan Huang [République populaire de Chine] ; JIE LUO [République populaire de Chine] ; HAO CHEN [République populaire de Chine] ; Xue-Mei Zhang [République populaire de Chine] ; Ji-Jun Chen [République populaire de Chine]

Source :

Bioorganic & medicinal chemistry letters : (Print) [ 0960-894X ] ; 2012.

RBID : Pascal:12-0355115

Descripteurs français

Pascal (Inist)
- Synthèse chimique, Activité biologique, Relation structure activité, Enoxolone, Antiviral, Virus hépatite B, Antiinflammatoire, Dérivé de l'oléanane, Triterpène, Terpénoïde.

English descriptors

KwdEn :
- Antiinflammatory agent, Antiviral, Biological activity, Chemical synthesis, Enoxolone, Hepatitis B virus, Oleanane derivatives, Structure activity relation, Terpenoid, Triterpene.

Abstract

Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds 29, 32, 35, 41 exhibited significantly inhibitory activities against HBV DNA replication with IC₅₀ values of 5.71, 5.36, 8.90 and 9.08 μM, respectively. The structure-activity relationships (SARs) of GA derivatives were discussed for exploring novel anti-HBV agents.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000052
to stream PascalFrancis, to step Curation: 000935
to stream PascalFrancis, to step Checkpoint: 000033
to stream Main, to step Merge: 001F84
to stream Main, to step Curation: 001F60

Le document en format XML

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<front><div type="abstract" xml:lang="en">Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds 29, 32, 35, 41 exhibited significantly inhibitory activities against HBV DNA replication with IC<sub>50</sub>
 values of 5.71, 5.36, 8.90 and 9.08 μM, respectively. The structure-activity relationships (SARs) of GA derivatives were discussed for exploring novel anti-HBV agents.</div>
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Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents

Synthesis, biological evaluation and structure-activity relationships of glycyrrhetinic acid derivatives as novel anti-hepatitis B virus agents

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